Metabolic Complementation in Bacterial Communities: Necessary Conditions and Optimality
نویسندگان
چکیده
Bacterial communities may display metabolic complementation, in which different members of the association partially contribute to the same biosynthetic pathway. In this way, the end product of the pathway is synthesized by the community as a whole. However, the emergence and the benefits of such complementation are poorly understood. Herein, we present a simple model to analyze the metabolic interactions among bacteria, including the host in the case of endosymbiotic bacteria. The model considers two cell populations, with both cell types encoding for the same linear biosynthetic pathway. We have found that, for metabolic complementation to emerge as an optimal strategy, both product inhibition and large permeabilities are needed. In the light of these results, we then consider the patterns found in the case of tryptophan biosynthesis in the endosymbiont consortium hosted by the aphid Cinara cedri. Using in-silico computed physicochemical properties of metabolites of this and other biosynthetic pathways, we verified that the splitting point of the pathway corresponds to the most permeable intermediate.
منابع مشابه
Sequential Optimality Conditions and Variational Inequalities
In recent years, sequential optimality conditions are frequently used for convergence of iterative methods to solve nonlinear constrained optimization problems. The sequential optimality conditions do not require any of the constraint qualications. In this paper, We present the necessary sequential complementary approximate Karush Kuhn Tucker (CAKKT) condition for a point to be a solution of a ...
متن کاملDeterminism and Contingency Shape Metabolic Complementation in an Endosymbiotic Consortium
Bacterial endosymbionts and their insect hosts establish an intimate metabolic relationship. Bacteria offer a variety of essential nutrients to their hosts, whereas insect cells provide the necessary sources of matter and energy to their tiny metabolic allies. These nutritional complementations sustain themselves on a diversity of metabolite exchanges between the cell host and the reduced yet h...
متن کاملOptimality conditions for approximate solutions of vector optimization problems with variable ordering structures
We consider nonconvex vector optimization problems with variable ordering structures in Banach spaces. Under certain boundedness and continuity properties we present necessary conditions for approximate solutions of these problems. Using a generic approach to subdifferentials we derive necessary conditions for approximate minimizers and approximately minimal solutions of vector optimizatio...
متن کاملOn Optimality Conditions via Weak Subdifferential and Augmented Normal Cone
In this paper, we investigate relation between weak subdifferential and augmented normal cone. We define augmented normal cone via weak subdifferential and vice versa. The necessary conditions for the global maximum are also stated. We produce preliminary properties of augmented normal cones and discuss them via the distance function. Then we obtain the augmented normal cone for the indicator f...
متن کامل